The 10th IDGF Workshop on Desktop Grid Computing will be held 27-30 September 2011 at the Universiti Putra in Serdang, Selangor, Malaysia. This workshop is organized by High Performance Computing Services Section, Laboratory of Computational Sciences and Mathematical Research (INSPEM) and jointly organized by InfoComm Development Center (iDEC) UPM. This workshop is fully supported by the International Desktop Grid Federation (IDGF) under the project of DEGISCO. The focus is on the Desktop Grid for eScience Roadmap: a new version has been published. A seminar on issues and opportunities in Desktop Grid is also presented.