The 10th IDGF Workshop on Desktop Grid Computing will be held 27-30 September 2011 at the Universiti Putra in Serdang, Selangor, Malaysia. This workshop is organized by High Performance Computing Services Section, Laboratory of Computational Sciences and Mathematical Research (INSPEM) and jointly organized by InfoComm Development Center (iDEC) UPM. This workshop is fully supported by the International Desktop Grid Federation (IDGF) under the project of DEGISCO. The focus is on the Desktop Grid for eScience Roadmap: a new version has been published. A seminar on issues and opportunities in Desktop Grid is also presented. The Workshop on Desktop Grid Computing will provide a platform for scientific users, Desktop Grid operation, system administrators and application developers to exchange experience about Desktop Grids and related technologies. The tutorials are useful for those who want to get an insight in the technologies provided by Desktop Grid systems, applications, and theoretical and practical knowledge about Desktop Grid Computing.