The Second International Conference "BOINC-based High Performance Computing: Fundamental Research and Development" is devoted to studying potential of distributed Desktop Grid computing, exchange of experience in creation and support of fundamental and applied BOINC projects. Among other, reports concerning technologies of development of distributed applications, processing of data, mathematical modeling of Desktop Grid, fundamental and applied BOINC projects will be presented. The conference will take place from 14 to 18 of September, 2015, in Petrozavodsk, Republic of Karelia. During the conference a meeting of the Russian Branch of "International Desktop Grid Federation" will be organized. Deadline for paper submission is April 20, 2015.